About This Information
This page summarizes important safety information for compounded semaglutide, which may be prescribed by an independent licensed provider through Trumino. It does not include everything you need to know. Talk with your provider about your medical history and all medications you take, and read the information that comes with your prescription.
Compounded semaglutide is prepared by a state-licensed pharmacy for an individual patient. Compounded medications are not FDA-approved and have not been reviewed by the FDA for safety, effectiveness or quality. The safety information below is based on the known effects of semaglutide. Trumino is not affiliated with Novo Nordisk, the maker of Ozempic® and Wegovy®.
Warning: Risk of Thyroid C-Cell Tumors
In studies in rodents, semaglutide caused thyroid C-cell tumors, including cancer. It is not known whether it causes these tumors, including medullary thyroid carcinoma (MTC), in people. Do not use semaglutide if you or a family member have ever had MTC, or if you have Multiple Endocrine Neoplasia syndrome type 2 (MEN 2). Tell your provider right away if you get a lump or swelling in your neck, hoarseness, trouble swallowing or shortness of breath.
Do Not Use If
- You or a family member have had medullary thyroid carcinoma, or you have MEN 2.
- You have had a serious allergic reaction to semaglutide or any ingredient in the formulation.
- You are pregnant, or plan to become pregnant (stop at least 2 months before a planned pregnancy).
Possible Serious Side Effects
- Inflammation of the pancreas (pancreatitis): severe stomach pain that will not go away, with or without vomiting, sometimes spreading to the back.
- Gallbladder problems: pain in the upper stomach, fever, yellowing of the skin or eyes, or clay-colored stools.
- Low blood sugar: higher risk if you also take insulin or a sulfonylurea. Signs include dizziness, shakiness, sweating, confusion, fast heartbeat and blurred vision.
- Kidney problems: dehydration from vomiting or diarrhea can worsen kidney function. Drink fluids to stay hydrated.
- Serious allergic reactions: swelling of the face, lips, tongue or throat, trouble breathing or swallowing, severe rash or itching, fainting or a very fast heartbeat.
- Changes in vision in people with type 2 diabetes.
- Increased heart rate.
- Depression or thoughts of suicide: watch for new or worsening mood changes and tell your provider.
- Food or liquid getting into the lungs during surgery or sedation: tell any clinician that you take semaglutide before a procedure.
Common Side Effects
Nausea, vomiting, diarrhea, constipation, stomach pain, headache, tiredness, upset stomach, dizziness, bloating, belching, gas and heartburn. Side effects are often more common when starting or increasing a dose.
Before You Start, Tell Your Provider
Tell your provider about all of your medical conditions and medications, including if you have had pancreatitis, gallbladder disease, kidney problems, diabetic eye disease, depression or suicidal thoughts, or if you are breastfeeding. Semaglutide slows stomach emptying and can affect how other oral medications are absorbed.
When to Get Help
Stop using the medication and seek medical care right away if you have signs of a serious allergic reaction, severe stomach pain, or any symptom that worries you. For emergencies, call 911. For non-urgent questions about your treatment, contact your provider through the patient portal. Report side effects to the FDA at fda.gov/medwatch or 1-800-FDA-1088.
Results
Individual results vary. Medication works best together with a reduced-calorie diet and increased physical activity. A provider determines whether treatment is right for you; a prescription is not guaranteed.